Minetto Giacomo, Raveglia Luca F, Taddei Maurizio
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
Org Lett. 2004 Feb 5;6(3):389-92. doi: 10.1021/ol0362820.
[reaction: see text] An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a beta-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal-Knorr procedure carried out under microwave irradiation.
[反应：见正文] 通过一个简单的三步程序获得了一系列四取代吡咯（和三取代呋喃）。β-酮酯与醛进行官能团同系化反应，然后氧化，得到了一系列不同取代的1,4-二羰基化合物，这些化合物可以在微波辐射下通过帕尔-克诺尔反应快速环化。
