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肠上皮细胞脂肪酸摄取与肠脂肪酸结合蛋白

Enterocyte fatty acid uptake and intestinal fatty acid-binding protein.

作者信息

Tso P, Nauli A, Lo C-M

机构信息

Department of Pathology, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267, USA.

出版信息

Biochem Soc Trans. 2004 Feb;32(Pt 1):75-8. doi: 10.1042/bst0320075.

Abstract

This article reviews our current understanding of the uptake of fatty acids by the enterocytes of the intestine. The micellar solubilization of fatty acids by bile salts and the factors regulating that process are discussed. The mechanism of how micellar solubilization of fatty acids promotes the uptake of fatty acids by enterocytes and their relative importance is reviewed. Additionally, discussion of the various fatty acid transporters located at the brush border membrane of the enterocytes is included. Finally, a summary of our current understanding of the function of fatty-acid-binding proteins inside enterocytes is provided.

摘要

本文综述了我们目前对肠道肠细胞摄取脂肪酸的理解。讨论了胆汁盐对脂肪酸的胶束增溶作用以及调节该过程的因素。回顾了脂肪酸的胶束增溶作用如何促进肠细胞摄取脂肪酸的机制及其相对重要性。此外,还讨论了位于肠细胞刷状缘膜上的各种脂肪酸转运蛋白。最后,总结了我们目前对肠细胞内脂肪酸结合蛋白功能的理解。

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