Ikonen E, Heino S, Lusa S
Institute of Biotechnology, University of Helsinki, 00251 Helsinki, Finland.
Biochem Soc Trans. 2004 Feb;32(Pt 1):121-3. doi: 10.1042/bst0320121.
Caveolae (small plasma membrane invaginations) and their coat proteins, caveolins, have attracted the attention of researchers in diverse fields, including cell biology, cardiovascular and cancer research. The tight association between caveolin and cholesterol governs the biochemical behaviour of caveolae and is emerging as an important characteristic in a number of processes assigned to these multifunctional organelles. In this review, selected aspects of the caveolin-cholesterol association and its potential functional implications are discussed.
小窝（质膜小内陷）及其包被蛋白小窝蛋白，已吸引了包括细胞生物学、心血管和癌症研究等不同领域研究人员的关注。小窝蛋白与胆固醇之间的紧密关联决定了小窝的生化行为，并正在成为赋予这些多功能细胞器的许多过程中的一个重要特征。在本综述中，将讨论小窝蛋白 - 胆固醇关联的选定方面及其潜在的功能影响。
