西地那非不能改善吸烟者中一氧化氮介导的内皮依赖性血管反应。
Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers.
作者信息
Dishy Victor, Harris Paul A, Pierce Rosanna, Prasad Harish C, Sofowora Gbenga, Bonar Holly L, Wood Alastair J J, Stein C Michael
机构信息
Division of Clinical Pharmacology, General Clinical Research Center, Department of Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN 37232-6602, USA.
出版信息
Br J Clin Pharmacol. 2004 Feb;57(2):209-12. doi: 10.1046/j.1365-2125.2003.01974.x.
AIMS
To examine the hypothesis that sildenafil, a phosphodiesterase type 5 inhibitor that inhibits cGMP breakdown, could enhance nitric oxide-mediated vasodilation and reverse endothelial dysfunction in chronic smokers.
METHODS
Flow-mediated dilation of the brachial artery and forearm postischemic reactive hyperemia (both nitric oxide-mediated responses) were measured before and after sildenafil 50 mg and placebo in a double-blind, randomized, crossover study in 9 men who were chronic smokers (21 +/- 3 pack years).
RESULTS
There was no significant change in flow-mediated dilation after either sildenafil (0.18%, 95%CI -1.7-2%) or placebo (0.24%, 95%CI -2.8-3.3%) (P = 0.88 and 0.8, respectively). Sildenafil had no significant effect on resting forearm blood flow or postischemic reactive hyperemia (P = 0.39 and 0.7, respectively). Resting heart rate and blood pressure were unaffected by sildenafil.
CONCLUSIONS
Acute sildenafil administration did not improve endothelial function in chronic smoking men.
目的
检验如下假设，即西地那非（一种抑制环磷酸鸟苷（cGMP）分解的5型磷酸二酯酶抑制剂）可增强一氧化氮介导的血管舒张作用并逆转慢性吸烟者的内皮功能障碍。
方法
在一项针对9名慢性吸烟者（吸烟量为21±3包年）的双盲、随机、交叉研究中，分别于服用50毫克西地那非和安慰剂前后测量肱动脉的血流介导的舒张功能以及前臂缺血后反应性充血（两者均为一氧化氮介导的反应）。
结果
服用西地那非（0.18%，95%置信区间为-1.7至2%）或安慰剂（0.24%，95%置信区间为-2.8至3.3%）后，血流介导的舒张功能均无显著变化（P值分别为0.88和0.8）。西地那非对静息状态下的前臂血流量或缺血后反应性充血均无显著影响（P值分别为0.39和0.7）。静息心率和血压不受西地那非影响。
结论
急性服用西地那非并不能改善慢性吸烟男性的内皮功能。
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