Fitzek Clemens, Haueisen Jens, Huonker Ralf, Reichenbach Jürgen R, Pfleiderer Stefan O R, Mentzel Hans-Joachim, Sauner Dieter, Brandl Ulrich, Kaiser Werner A
Institute of Diagnostic and Interventional Radiology/AB Neuroradiology MRI, Friedrich-Schiller-Universität Jena, Germany.
Radiology. 2004 Mar;230(3):715-9. doi: 10.1148/radiol.2303021529. Epub 2004 Jan 28.
To investigate whether routine magnetic resonance (MR) imaging of the brain with a whole-body 1.5-T imager affects the results of subsequent magnetoencephalography (MEG).
Nine healthy volunteers (six women, mean age of 23 years, age range of 20-27 years; three men, mean age of 24 years, age range of 23-25 years) underwent one MEG session before and two MEG sessions after MR imaging of the brain. The first MEG session was completed about 20 minutes before brain MR imaging began, the second MEG session (MEG 2) was performed within 30 minutes after MR imaging, and the third MEG session was performed 2 hours after MEG 2. Each MEG session involved measurement of spontaneous brain activity and, in seven patients, of brain activity during stimulation of the median nerve. MR imaging included T1- and T2-weighted fast spin-echo and gradient-echo sequences applied with a 1.5-T clinical imager. Data were compared by using a repeated-measures analysis of variance (general linear model) both with and without Greenhouse-Geisser correction.
MEG signals were detected and measured without difficulty in all volunteers. No statistically significant difference was seen between estimated noise at MEG before and after MR imaging (P =.588 with correction, P =.665 without correction). MEG records obtained in all volunteers enabled localization of evoked response to median nerve stimulation before and after MR imaging. No measurable differences were observed between relative power spectra of spontaneous brain activity before and after MR imaging (P >.290 with correction, P >or=.295 without correction).
No measurable effect of 1.5-T brain MR imaging on subsequent MEG was detected.
研究使用全身1.5-T成像仪对大脑进行常规磁共振（MR）成像是否会影响后续的脑磁图（MEG）结果。
9名健康志愿者（6名女性，平均年龄23岁，年龄范围20 - 27岁；3名男性，平均年龄24岁，年龄范围23 - 25岁）在大脑MR成像前进行了一次MEG检查，成像后进行了两次MEG检查。第一次MEG检查在大脑MR成像开始前约20分钟完成，第二次MEG检查（MEG 2）在MR成像后30分钟内进行，第三次MEG检查在MEG 2后2小时进行。每次MEG检查都包括测量自发脑活动，7名患者还包括测量正中神经刺激期间的脑活动。MR成像包括使用1.5-T临床成像仪应用的T1加权和T2加权快速自旋回波及梯度回波序列。数据通过使用重复测量方差分析（一般线性模型）进行比较，采用和不采用Greenhouse-Geisser校正。
所有志愿者均能轻松检测和测量MEG信号。MR成像前后MEG估计噪声之间未见统计学显著差异（校正后P = 0.588，未校正P = 0.665）。所有志愿者获得的MEG记录能够在MR成像前后定位对正中神经刺激的诱发反应。MR成像前后自发脑活动的相对功率谱之间未观察到可测量的差异（校正后P > 0.290，未校正P≥0.295）。
未检测到1.5-T大脑MR成像对后续MEG有可测量的影响。
