Melting of complexes of DNA-cis-DDP in acidic environment.
作者信息
Dalyan Y B, Haroutiunian T S, Haroutiunian S G, Vardevanyan P O
机构信息
Department of Molecular Physics of the Physical Faculty, 375025 Yerevan, Alek Manoogian St., 1, Armenia.
出版信息
Exp Mol Med. 2003 Dec 31;35(6):534-7. doi: 10.1038/emm.2003.69.
PMID:14749531
Abstract
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior T (pH) and T(m) (pH) DNA at pH 2.8-3.0 are possible to explain by formation in DNA of pseudo-ring structures at covalent linking of cis-DDP with DNA.
摘要
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