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室外空气污染与哮喘。

Outdoor air pollution and asthma.

作者信息

Wong Gary W K, Lai Chris K W

机构信息

Department of Paediatrics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.

出版信息

Curr Opin Pulm Med. 2004 Jan;10(1):62-6. doi: 10.1097/00063198-200401000-00011.

Abstract

PURPOSE OF REVIEW

The relation between outdoor air pollution and asthma has always been a major focus of research. The evidence that current levels of air pollution in many countries result in increased morbidity and mortality is fairly consistent. With rapid urbanization in many communities, traffic exhausts have become the major source of pollution, and many recent research studies have attempted to investigate the detrimental effects of this type of pollution. This paper reviews the recent evidence of the possible detrimental effects of ambient air pollution on the inception and morbidity of asthma.

RECENT FINDINGS

Traffic related pollution has been confirmed in both cross-sectional and longitudinal studies to be associated with increased asthma morbidity and cardiopulmonary mortality. There is also evidence that pollutants such as ozone and traffic exhausts may be responsible for new incident cases of asthma. Among the particulate pollution, research investigating the ultrafine particles and the bacterial components suggested that these particles may have important role in asthma morbidity.

SUMMARY

More research studies are needed to reveal how various air pollutants may interact with the host systems, such as the immune system, leading to increased morbidity in susceptible individuals. Reduction of the current levels of ambient air pollution should be an integral part of the overall effort in minimizing asthma morbidity or mortality in the community.

摘要

综述目的

室外空气污染与哮喘之间的关系一直是研究的重点。许多国家目前的空气污染水平导致发病率和死亡率上升,这方面的证据相当一致。随着许多社区的快速城市化,交通尾气已成为主要污染源,最近许多研究试图调查这类污染的有害影响。本文综述了近期有关环境空气污染对哮喘发病和发病率可能产生有害影响的证据。

最新发现

横断面研究和纵向研究均证实,与交通相关的污染与哮喘发病率增加和心肺死亡率有关。还有证据表明,臭氧和交通尾气等污染物可能是哮喘新发病例的原因。在颗粒物污染方面,对超细颗粒和细菌成分的研究表明,这些颗粒可能在哮喘发病中起重要作用。

总结

需要更多的研究来揭示各种空气污染物如何与宿主系统(如免疫系统)相互作用,从而导致易感个体的发病率增加。降低当前的环境空气污染水平应成为社区降低哮喘发病率或死亡率整体努力的一个组成部分。

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