Riskin-Mashiah Shlomit, Belfort Michael A, Saade George R, Herd Alan J
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA.
Am J Obstet Gynecol. 2004 Jan;190(1):194-8. doi: 10.1016/j.ajog.2003.07.005.
This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women.
Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 x Rt-Lt//(Rt+Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P<.05.
Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R>0.8, P<.0001), PI (R>0.6, P.0001), and CPP (R>0.8, P<.0001). There were no differences in the asymmetry index for Vm, PI, or CPP between the two groups.
Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.
本研究旨在调查与血压正常的孕妇相比，先兆子痫妇女的大脑中动脉（MCA）左右两侧速度差异是否更大。
在孕晚期对41名先兆子痫妇女和50名血压正常的孕妇进行研究。采用经颅多普勒超声测量双侧MCA的峰值、舒张末期和平均速度。计算以下每个参数的不对称指数：平均速度（Vm）、搏动指数（PI）和脑灌注压（CPP），计算方法为100×（右 - 左）/[（右 + 左）/2]。使用学生t检验、Pearson相关性分析和回归分析。显著性水平设定为P<0.05。
血压正常和先兆子痫的孕妇双侧MCA的Vm（R>0.8，P<0.0001）、PI（R>0.6，P<0.0001）和CPP（R>0.8，P<0.0001）之间均显示出良好的相关性。两组之间Vm、PI或CPP的不对称指数没有差异。
先兆子痫似乎不会在MCA分布中引起更大的左右两侧速度差异。
