Bioavailability of selenium from bovine milk as assessed in subjects with ileostomy.

OBJECTIVE

To assess the absorption of dietary selenium in humans, especially of milk selenium.

DESIGN

: 1-day meal studies in subjects with ileostomy.

SETTING

Hospital outpatient clinics.

SUBJECTS

Three subjects in the pilot study and nine subjects in the main study (eight men/ four women).

INTERVENTION

Different beverages, 1 l/day, were given in addition to basal diets (soft drink, 1 week; low-fat milk, 3 weeks; fermented low-fat milk, 3 weeks and soft drink, 1 week). Ileostomy effluents were collected during the last 2 days in each of the four periods.

RESULTS

On days when the subjects were given 1 l of low-fat milk, the estimated fractional absorption of total dietary selenium was 65.5 (2.3)% (mean (s.d.), n=18), which was similar to the value when fermented low-fat milk was given (64.1 (3.2)%). However, both the calculated amount of milk selenium absorbed (10.9 (2.4) vs 9.4 (1.7) microg selenium) and its fractional absorption (73.3 (16.1) vs 64.1 (11.2)%, n=18) were significantly higher for milk than for fermented milk.

CONCLUSIONS

Selenium from milk and other sources is well absorbed in subjects with ileostomy. The real absorption may be even higher than the values shown.