Ozanne Susan E, Hales C Nicholas
Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, UK.
Nature. 2004 Jan 29;427(6973):411-2. doi: 10.1038/427411b.
Poor fetal growth is linked with long-term detrimental effects on health in adulthood. Here we investigate whether the lifespan of male mice is affected by their growth rate when they were suckling and find that limiting growth during that period not only increases longevity but also protects against the life-shortening effect of an obesity-inducing diet later on. By contrast, we find that lifespan is considerably shortened if the postnatal period of growth is accelerated to make up for reduced growth in utero, and that, in addition, these mice are susceptible to the adverse effects on longevity of an obesity-inducing diet after weaning.
胎儿生长发育不良与成年期长期健康损害有关。在此，我们研究雄性小鼠哺乳期的生长速度是否会影响其寿命，结果发现，在此期间限制生长不仅能延长寿命，还能抵御后期致肥胖饮食导致的寿命缩短效应。相比之下，我们发现，如果加速出生后的生长期以弥补子宫内生长的不足，寿命会显著缩短，此外，这些小鼠在断奶后也易受致肥胖饮食对寿命的不利影响。
