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[自发性颅内低压。一种有良好治疗选择的罕见综合征]

[Spontaneous intracranial hypotension. A rare syndrome with good treatment options].

作者信息

Bachmann-Mennenga B, Philipps J, Haukamp F, Reinbold W D

机构信息

Klinik für Anästhesiologie, Klinikum Minden.

出版信息

Anaesthesist. 2004 Jan;53(1):45-52. doi: 10.1007/s00101-003-0601-0.

DOI:10.1007/s00101-003-0601-0
PMID:14749876
Abstract

The spontaneous intracranial hypotension syndrome is a rare event but with increasing tendency. The clinical characteristics are comparable to those occurring after dural puncture and the most important clinical finding is the postural headache. The syndrome results from cerebrospinal fluid leakage but its etiology is still nearly unknown. The leaks are mainly located cervically or at the cervicothoracic junction. The syndrome may be associated with cranial subdural fluid build-up. Magnetic resonance imaging of the brain typically reveals diffuse pachymeningeal enhancement, frequently in association with displacement of the brain. Knowledge of this can be helpful to facilitate the diagnosis. Although conservative measures are often initially undertaken, placement of an epidural blood patch is the treatment of choice. Because of its similarity to postdural puncture headache, anaesthesiologists and pain therapists are increasingly involved in diagnosis and therapy. We report 2 patients with spontaneous intracranial hypotension. In addition to the cardinal feature of a postural headache, the patients suffered from subdural fluid build-up demonstrated by cranial magnetic resonance imaging.

摘要

自发性颅内低压综合征是一种罕见但有增加趋势的病症。其临床特征与硬膜穿刺后出现的特征相似,最重要的临床发现是体位性头痛。该综合征由脑脊液漏引起,但其病因仍几乎未知。漏液主要位于颈部或颈胸交界处。该综合征可能与颅硬膜下积液有关。脑部磁共振成像通常显示弥漫性硬脑膜强化,常伴有脑移位。了解这一点有助于促进诊断。虽然通常最初采取保守措施,但硬膜外血贴是首选治疗方法。由于其与硬膜穿刺后头痛相似,麻醉医生和疼痛治疗师越来越多地参与到诊断和治疗中。我们报告了2例自发性颅内低压患者。除了体位性头痛这一主要特征外,患者还出现了颅磁共振成像显示的硬膜下积液。

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引用本文的文献

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[Spontaneous intracranial hypotension and Marfan syndrome].[自发性颅内低压与马方综合征]
Nervenarzt. 2016 Aug;87(8):846-52. doi: 10.1007/s00115-016-0126-9.

本文引用的文献

1
Low Cerebrospinal Fluid Pressure Headache.低脑脊液压力性头痛
Curr Treat Options Neurol. 2002 Sep;4(5):357-363. doi: 10.1007/s11940-002-0046-9.
2
Cervical MR imaging in postural headache: MR signs and pathophysiological implications.姿势性头痛的颈椎磁共振成像:磁共振征象及病理生理意义
AJNR Am J Neuroradiol. 2001 Aug;22(7):1239-50.
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Spontaneous intracranial hypotension.自发性颅内低压
Curr Pain Headache Rep. 2001 Jun;5(3):284-91. doi: 10.1007/s11916-001-0045-7.
4
Why are postdural puncture headaches still a problem?为什么硬膜穿刺后头痛仍然是个问题?
Reg Anesth Pain Med. 2000 Jul-Aug;25(4):347-9. doi: 10.1053/rapm.2000.3028.
5
[Spontaneous intracranial hypotension syndrome. Clinical, neuroradiological and cerebrospinal fluid findings].[自发性颅内低压综合征。临床、神经放射学及脑脊液检查结果]
Nervenarzt. 1999 Oct;70(10):909-15. doi: 10.1007/s001150050595.
6
Epidural fibrin glue injection stops persistent postdural puncture headache.硬膜外注射纤维蛋白胶可治愈持续性硬膜穿刺后头痛。
Anesthesiology. 1999 Aug;91(2):576-7. doi: 10.1097/00000542-199908000-00039.
7
Orthostatic headaches caused by CSF leak but with normal CSF pressures.由脑脊液漏引起但脑脊液压力正常的体位性头痛。
Neurology. 1998 Sep;51(3):786-90. doi: 10.1212/wnl.51.3.786.
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Spontaneous intracranial hypotension: spinal MR findings.自发性颅内低压:脊髓磁共振成像表现
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9
Spinal dural enhancement on magnetic resonance imaging associated with spontaneous intracranial hypotension. Report of three cases and review of the literature.磁共振成像显示的与自发性颅内低压相关的硬脊膜强化。三例报告并文献复习。
J Neurosurg. 1998 May;88(5):912-8. doi: 10.3171/jns.1998.88.5.0912.
10
Surgical treatment of spontaneous spinal cerebrospinal fluid leaks.自发性脊柱脑脊液漏的外科治疗
J Neurosurg. 1998 Feb;88(2):243-6. doi: 10.3171/jns.1998.88.2.0243.