骨髓瘤化疗后塌陷型局灶节段性肾小球硬化症缓解

Remission of collapsing focal segmental glomerulosclerosis following chemotherapy for myeloma.

作者信息

Shah Sapna, Cavenagh Jamie, Sheaf Michael, Thuraisingham Raj C

机构信息

Department of Renal Medicine, Barts and the London NHS Trust, London, UK.

出版信息

Am J Kidney Dis. 2004 Feb;43(2):e10-2. doi: 10.1053/j.ajkd.2003.10.036.

DOI:10.1053/j.ajkd.2003.10.036

PMID:14750118

Abstract

Collapsing focal segmental glomerulosclerosis can be idiopathic but has been associated with human immunodeficiency virus infection as well as lymphoproliferative, myeloproliferative, and autoimmune disorders. It has a more rapid progression to end-stage renal failure. Treatment of this condition is poorly defined with no clear evidence of response to any treatment regimens. We report a case of collapsing focal segmental glomerulosclerosis in association with multiple myeloma that underwent partial remission following treatment for the underlying disease.

摘要

塌陷型局灶节段性肾小球硬化可为特发性，但也与人类免疫缺陷病毒感染以及淋巴增殖性、骨髓增殖性和自身免疫性疾病相关。它向终末期肾衰竭进展更快。这种疾病的治疗方法尚不明确，没有明确证据表明对任何治疗方案有反应。我们报告一例与多发性骨髓瘤相关的塌陷型局灶节段性肾小球硬化病例，在对基础疾病进行治疗后病情部分缓解。