Hulihan-Giblin B A, Park Y D, Aulakh C S, Goldman D
Laboratory of Neurogenetics, National Institute on Alcoholism and Alcohol Abuse, Bethesda, MD 20892.
Neuropharmacology. 1992 Nov;31(11):1095-9. doi: 10.1016/0028-3908(92)90004-9.
The Fawn-Hooded strain of rats exhibits a hemorrhagic disorder, known as platelet storage pool deficiency. In addition to the platelet dysfunction, there is an altered response to certain serotonin drugs. To assess the characteristics of the binding to 5-HT1A and 5-HT2 receptors in this strain, regions of the brain from Fawn-Hooded, Sprague-Dawley and Wistar male rats were examined. The drug [3H]8-OH-DPAT was used to label 5-HT1A receptors and the Kd values for frontal cortex, hippocampus, striatum, hypothalamus and brainstem were similar in all three strains of rat. As with the 5-HT1A receptors, no differences were observed in the Kd values for 5-HT2 receptors, in any of the regions examined, among the three strains. However, the Bmax for the binding of [3H]8-OH-DPAT in the striatum and brainstem of Fawn-Hooded rats was less than in the Sprague-Dawley and Wistar animals. Furthermore, 5-HT2 receptors displayed a greater Bmax value in the striatum and in the frontal cortex of Fawn-Hooded animals, compared to Sprague-Dawley and Wistar rats. These differences in receptors are consistent with previous studies in which Fawn-Hooded rats were found to have altered serotonergic function, relative to Wistar and Sprague-Dawley animals.
小鹿斑比毛色品系的大鼠表现出一种出血性疾病，称为血小板储存池缺陷。除了血小板功能障碍外，对某些血清素药物的反应也有所改变。为了评估该品系大鼠与5-HT1A和5-HT2受体结合的特征，对小鹿斑比毛色、斯普拉格-道利和Wistar雄性大鼠的脑区进行了检查。药物[3H]8-OH-DPAT用于标记5-HT1A受体，在所有三种品系的大鼠中，额叶皮质、海马体、纹状体、下丘脑和脑干的Kd值相似。与5-HT1A受体一样，在三个品系的任何检查区域中，5-HT2受体的Kd值均未观察到差异。然而，小鹿斑比毛色大鼠纹状体和脑干中[3H]8-OH-DPAT结合的Bmax低于斯普拉格-道利和Wistar动物。此外，与斯普拉格-道利和Wistar大鼠相比，小鹿斑比毛色动物纹状体和额叶皮质中的5-HT2受体显示出更大的Bmax值。这些受体差异与先前的研究一致，在先前研究中发现，相对于Wistar和斯普拉格-道利动物，小鹿斑比毛色大鼠的血清素能功能发生了改变。
