GENIUS II：一个用于将完整基因组中的开放阅读框与已知蛋白质三维结构相链接的高通量数据库系统。

GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures.

作者信息

Yabuki Yukimitsu, Mukai Yuri, Swindells Mark B, Suwa Makiko

机构信息

Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi Frontier Building 17F, 2-43 Aomi, Koto-ku, Tokyo 135-0064, Japan.

出版信息

Bioinformatics. 2004 Mar 1;20(4):596-8. doi: 10.1093/bioinformatics/btg478. Epub 2004 Jan 29.

DOI:10.1093/bioinformatics/btg478

PMID:14751990

Abstract

GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) structures. The system uses the multiple intermediate sequence search method in which query and target sequences are linked by intermediate sequences gathered by PSI-BLAST search. By applying the system to 129 complete genomes, 43.8% on average of the ORFs in the genomes were assigned to known 3D structures and the results are available for free at GENIUS II web site.

摘要

GENIUS II是一个自动化数据库系统，其中完整基因组中的开放阅读框（ORF）被分配给已知的蛋白质三维（3D）结构。该系统使用多重中间序列搜索方法，通过PSI-BLAST搜索收集的中间序列将查询序列和目标序列联系起来。通过将该系统应用于129个完整基因组，基因组中平均43.8%的开放阅读框被分配给已知的三维结构，结果可在GENIUS II网站上免费获取。