多次高压氧疗可扩大大鼠急性脊髓损伤的治疗窗口。

Multiple hyperbaric oxygenation (HBO) expands the therapeutic window in acute spinal cord injury in rats.

作者信息

Huang L, Mehta M P, Eichhorn J H, Nanda A, Zhang J H

机构信息

Department of Anesthesiology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

出版信息

Acta Neurochir Suppl. 2003;86:433-8. doi: 10.1007/978-3-7091-0651-8_89.

DOI:10.1007/978-3-7091-0651-8_89

PMID:14753481

Abstract

Hyperbaric oxygenation (HBO) therapy has been reported to improve neurological recovery following spinal cord injury (SCI). In the present study, we examined whether multiple HBO expands the therapeutic window for acute SCI. Single HBO (2.8 ATA, 1 hour) treatment was used at 30 minutes, 3 hours, and 6 hours following SCI, and serial HBO treatment (once daily for 1 week) at 6 hours and 24 hours post-injury. Mild SCI was induced by adjusting the height for a weight drop insult (10 g) to 6.25 mm above the exposed spinal cord. The group of animals receiving a single HBO intervention beginning at 30 minutes and 3 hours, or serial HBO treatment starting at 6 hours following the injury had a significantly better neurological recovery than animals with SCI only. The results of this study demonstrate that multiple HBO expands the therapeutic window for acute SCI to 6 hours after injury, further that serial HBO administration is superior to single HBO therapy.

摘要

据报道，高压氧（HBO）疗法可改善脊髓损伤（SCI）后的神经功能恢复。在本研究中，我们研究了多次高压氧治疗是否能扩大急性脊髓损伤的治疗窗口期。在脊髓损伤后30分钟、3小时和6小时采用单次高压氧（2.8 ATA，1小时）治疗，并在损伤后6小时和24小时进行连续高压氧治疗（每天1次，共1周）。通过将重物下落致伤（10 g）的高度调整为暴露脊髓上方6.25 mm来诱导轻度脊髓损伤。在损伤后30分钟和3小时开始接受单次高压氧干预，或在损伤后6小时开始接受连续高压氧治疗的动物组，其神经功能恢复明显优于仅患有脊髓损伤的动物。本研究结果表明，多次高压氧治疗可将急性脊髓损伤的治疗窗口期延长至损伤后6小时，进一步表明连续高压氧治疗优于单次高压氧治疗。