散发性克雅氏病嗅觉活检中的朊病毒沉积

Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease.

作者信息

Tabaton Massimo, Monaco Salvatore, Cordone Maria Paola, Colucci Monica, Giaccone Giorgio, Tagliavini Fabrizio, Zanusso Gianluigi

机构信息

Department of Neurosciences, University of Genoa, Genoa, Italy.

出版信息

Ann Neurol. 2004 Feb;55(2):294-6. doi: 10.1002/ana.20038.

DOI:10.1002/ana.20038

PMID:14755736

Abstract

Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.

摘要

目前，尚无用于散发性克雅氏病（CJD）体内诊断的确切外周标志物。在此，我们报告了一例散发性克雅氏病患者嗅黏膜中存在病理性朊蛋白。在疾病发作45天后进行的嗅黏膜活检中检测到朊蛋白免疫反应性，这表明嗅上皮受累是散发性克雅氏病的早期事件。