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锌补充剂用于铅中毒螯合疗法的初步研究。

Zinc supplementation of chelation therapy in saturnism. Preliminary study.

作者信息

Bădulici S, Chirilă M

机构信息

Christiana Center of Social Medicine, Bucharest, Romania.

出版信息

Rom J Intern Med. 1992 Jul-Sep;30(3):211-5.

PMID:1475600
Abstract

The effect of zinc supplementation of chelation therapy in saturnism was studied in 20 patients hospitalized in the Clinic of Occupational Diseases of the Colentina Hospital. In 10 patients 400 mg/day zinc sulphate in two uptakes was administered concomitantly with the chelation therapy. The other 10 patients received only chelation therapy. The period necessary for the correction of the anemic syndrome was estimated comparatively by studying the evolution of the following parameters: hemoglobin, reticulocytes, red blood cells with basophilic granulations. Zinc supplementation of the chelation therapy had a favourable effect by reducing the necessary period for the correction of anemic syndrome.

摘要

在科伦蒂纳医院职业病诊所住院的20例铅中毒患者中,研究了补充锌对螯合疗法治疗铅中毒的效果。10例患者在进行螯合治疗的同时,每天分两次服用400毫克硫酸锌。另外10例患者仅接受螯合治疗。通过研究以下参数的变化,比较评估了纠正贫血综合征所需的时间:血红蛋白、网织红细胞、有嗜碱性颗粒的红细胞。螯合疗法补充锌通过缩短纠正贫血综合征所需的时间产生了有利效果。

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