[肾素-血管紧张素系统激活的替代途径]

[Alternative pathways for the activation of the renin-angiotensin system].

作者信息

Gurzu B, Costuleanu M, Petrescu Gh

机构信息

Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2003 Oct-Dec;107(4):710-7.

PMID:14756007

Abstract

The knowledge of the structure and function of the components of the renin-angiotensin system (RAS) is rapidly increasing. The classic pathway of angiotensin (Ang) II generation includes a reaction catalyzed by angiotensin-converting enzyme (ACE). We actually discuss the alternative pathways for the generation of Ang-II and other angiotensin peptides (Ang III, Ang IV, Ang (1-9), Ang (1-7), des-Asp-Ang I) and the responsible enzymes (tonins, cathepsins, chymases, aminopeptidases, dipeptidyl aminopeptidases, neutral endopeptidases, carboxypeptidases, ACE2 etc.). The development of novel enzyme inhibitors (e.g., nafamostat, sampatrilat) for more efficacious suppression of RAS activity is also considered.

摘要

肾素-血管紧张素系统（RAS）各组成部分的结构和功能知识正在迅速增加。血管紧张素（Ang）II生成的经典途径包括由血管紧张素转换酶（ACE）催化的反应。我们实际上讨论了Ang-II和其他血管紧张素肽（Ang III、Ang IV、Ang (1-9)、Ang (1-7)、去天冬氨酸-Ang I）生成的替代途径以及相关酶（组织蛋白酶、组织蛋白酶、糜蛋白酶、氨肽酶、二肽基氨肽酶、中性内肽酶、羧肽酶、ACE2等）。还考虑了开发新型酶抑制剂（如那法莫司他、替米沙坦）以更有效地抑制RAS活性。