[某些新型甲基黄嘌呤衍生物的心血管特性研究]

[Study of the cardiovascular properties of some new methyl-xanthine derivatives].

作者信息

Profire Lenuţa, Dănilă Gh, Nechifor M

机构信息

Disciplina de Chimie Farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2003 Oct-Dec;107(4):872-6.

PMID:14756037

Abstract

The effects of some new methylxanthine compounds, derivatives of theophylline, theobromine and caffeine with various radicals in 8 position on blood pressure have been studied. Derivatives of theophylline (1,3-dimethyl-xanthine) with various radicals in 8 position have reduced the blood pressure. In the same experimental conditions the theobromine (3,7-dimethyl-xanthine) derivatives haven't modified the blood pressure while the caffeine (1,3,7-trimethyl-xanthine) derivatives have increased the blood pressure values.

摘要

研究了一些新的甲基黄嘌呤化合物（茶碱、可可碱和咖啡因在8位带有各种基团的衍生物）对血压的影响。8位带有各种基团的茶碱（1,3 - 二甲基黄嘌呤）衍生物可降低血压。在相同实验条件下，可可碱（3,7 - 二甲基黄嘌呤）衍生物未改变血压，而咖啡因（1,3,7 - 三甲基黄嘌呤）衍生物则使血压值升高。