Inoue Hiroko, Kobayashi-Hattori Kazuo, Horiuchi Yumi, Oishi Yuichi, Arai Souichi, Takita Toshichika
Department of Nutritional Science, Faculty of Applied Bio-Science, Tokyo University of Agriculture, Tokyo, Japan.
Biosci Biotechnol Biochem. 2006 May;70(5):1134-9. doi: 10.1271/bbb.70.1134.
We investigated the regulatory effects of structural differences among methylxanthine derivatives on the elevation of body fat percentage in developmental-stage rats. Caffeine, theophylline and theobromine were used as the methylxanthines. High-fat diets (20% lard) containing each methylxanthine (0.025%) were administered to male Sprague-Dawley rats for 12 weeks, with the result that the body fat percentage was generally reduced in each methylxanthine-fed group. The abdominal adipose tissue weight in the caffeine group was also significantly lower than that in the control group, the serum cholesterol and triglyceride levels in the caffeine group also being significantly lower than the levels in the control group. The study results suggest that caffeine could contribute most to preventing arteriosclerotic diseases.
我们研究了甲基黄嘌呤衍生物结构差异对发育阶段大鼠体脂百分比升高的调节作用。咖啡因、茶碱和可可碱用作甲基黄嘌呤。将含有每种甲基黄嘌呤（0.025%）的高脂饮食（20%猪油）给予雄性斯普拉格-道利大鼠12周，结果是每个甲基黄嘌呤喂养组的体脂百分比普遍降低。咖啡因组的腹部脂肪组织重量也显著低于对照组，咖啡因组的血清胆固醇和甘油三酯水平也显著低于对照组。研究结果表明，咖啡因对预防动脉粥样硬化疾病的贡献最大。
