Erenoğlu C, Uluutku H, Emeksiz S, Akin M L, Foley E, Celenk T
Department of General Surgery, GATA Haydarpaşa Training Hospital, Kadiköy/ Istanbul, Turkey.
Undersea Hyperb Med. 2003 Winter;30(4):321-6.
This study investigates the effects of hyperbaric oxygen (HBO2) therapy on the healing capacity of colonic anastomoses under the influence of preoperative chemotherapy.
Forty male Wistar-Albino rats were divided into four groups of 10. Colonic resection and anastomosis were performed in each group. Group I (control) received no further treatment. In group II, 5-fluorouracil was administered intraperitoneally for five consecutive days preoperatively. Group III received HBO2 therapy for seven days after the anastomosis. Group IV received HBO2 therapy following the administration of preoperative 5-fluorouracil. On the seventh postoperative day, all the rats were examined to determine the bursting pressures of the anastomosis and to take tissue sample from the anastomotic line for hydroxyproline measurement.
Bursting pressures of the anastomosis in group IV were increased significantly compared to group II. Hydroxyproline levels were significantly increased with the use of HBO2 in rats, independent of chemotherapy administration.
HBO2 therapy strengthens anastomoses created under the influence of neoadjuvant chemotherapy. This technique might have a future role in the care of colon cancer patients undergoing new multimodality cancer treatments.
本研究探讨高压氧（HBO2）疗法对术前化疗影响下结肠吻合口愈合能力的作用。
40只雄性Wistar白化大鼠分为四组，每组10只。每组均行结肠切除及吻合术。第一组（对照组）未接受进一步治疗。第二组在术前连续5天腹腔注射5-氟尿嘧啶。第三组在吻合术后接受7天的HBO2治疗。第四组在术前给予5-氟尿嘧啶后接受HBO2治疗。术后第7天，检查所有大鼠以测定吻合口的破裂压力，并从吻合线处取组织样本进行羟脯氨酸测量。
与第二组相比，第四组吻合口的破裂压力显著增加。无论是否给予化疗，使用HBO2均可使大鼠体内羟脯氨酸水平显著升高。
HBO2疗法可增强新辅助化疗影响下形成的吻合口。该技术可能在接受新型多模式癌症治疗的结肠癌患者护理中发挥未来作用。
