肿瘤内CD8 + T淋巴细胞在肝外胆管癌中的预后价值作为重要的免疫反应
Prognostic value of intratumoral CD8+ T lymphocyte in extrahepatic bile duct carcinoma as essential immune response.
作者信息
Oshikiri Taro, Miyamoto Masaki, Shichinohe Toshiaki, Suzuoki Masato, Hiraoka Kei, Nakakubo Yoshihiro, Shinohara Toshiya, Itoh Tomoo, Kondo Satoshi, Katoh Hiroyuki
机构信息
Department of Surgical Oncology, Cancer Medicine, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
出版信息
J Surg Oncol. 2003 Dec;84(4):224-8. doi: 10.1002/jso.10321.
BACKGROUND AND OBJECTIVES
Tumor-infiltrating lymphocytes form an important aspect of the host defense against an expanding neoplasm. CD8+ T cells have been identified as a prognostic factor in several cancers. Here, we investigate that the influence of CD8+ T cells on extrahepatic bile duct carcinoma (EBDC) patient survival.
METHODS
CD8+ T cell immunoreactivity in 58 surgically resected EBDC specimens was investigated. The relationship between CD8+ T cell immunoreactivity and clinical and histopathologic features was analyzed.
RESULTS
Thirty-two tumors (55%) possessed intratumoral CD8+ T cells. The degree of intratumoral CD8+ T cell immunoreactivity demonstrated a significant relationship to lower numbers of lymph node metastasis, reduced venous invasion, decreased perineural invasion, and better pTNM staging. Intratumoral CD8- T cells were also associated with increased patient survival. Multivariate analysis indicated that the presence of intratumoral CD8+ T cells was an independent prognostic factors.
CONCLUSIONS
The infiltration of a cancer cell nest by CD8+ T cells is a reliable marker predicting increased survival of patients with EBDC.
背景与目的
肿瘤浸润淋巴细胞是宿主抵御不断扩大的肿瘤的重要组成部分。CD8 + T细胞已被确定为多种癌症的预后因素。在此，我们研究CD8 + T细胞对肝外胆管癌（EBDC）患者生存的影响。
方法
对58例手术切除的EBDC标本中的CD8 + T细胞免疫反应性进行研究。分析CD8 + T细胞免疫反应性与临床和组织病理学特征之间的关系。
结果
32例肿瘤（55%）存在瘤内CD8 + T细胞。瘤内CD8 + T细胞免疫反应程度与淋巴结转移数量减少、静脉侵犯减少、神经周围侵犯减少以及更好的pTNM分期显著相关。瘤内CD8 + T细胞也与患者生存率增加相关。多因素分析表明，瘤内CD8 + T细胞的存在是一个独立的预后因素。
结论
CD8 + T细胞浸润癌细胞巢是预测EBDC患者生存率提高的可靠标志物。
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