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[青少年动脉高血压中体液系统的变化及其通过硝苯地平和心得安的纠正]

[Changes in the humoral systems in juvenile arterial hypertension and their correction by using nifedipine and anaprilin].

作者信息

Bihar P V

出版信息

Lik Sprava. 1992 Aug(8):67-9.

PMID:1475932
Abstract

Examined were 140 adolescents with juvenile arterial hypertension (JAH) and 54 healthy adolescents (age: 15-19 years). Niphedipine was used in 36, anaprilin in 40; 60--did not receive these drugs (control group). The treatment lasted 6 months. It was found that before treatment adolescents with JAH showed a clear increase of the angiotensin, testosterone and plasma renin activity (PRA). Niphedipine treatment resulted in normalization of the angiotensin level, while anaprilin treatment resulted in normalization of PRA and testosterone. The two drugs reduced equally the level of arterial pressure.

摘要

研究对象为140名患有青少年动脉高血压（JAH）的青少年以及54名健康青少年（年龄：15 - 19岁）。36名使用硝苯地平，40名使用心得安；60名未接受这些药物治疗（对照组）。治疗持续6个月。结果发现，治疗前患有JAH的青少年血管紧张素、睾酮和血浆肾素活性（PRA）明显升高。硝苯地平治疗使血管紧张素水平恢复正常，而心得安治疗使PRA和睾酮恢复正常。两种药物降低动脉血压的程度相同。

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