Morice P, Deyrolle C, Rey A, Atallah D, Pautier P, Camatte S, Thoury A, Lhomme C, Haie-Meder C, Castaigne D
Department of Gynecologic Surgery, Institut Gustave Roussy, Villejuif, France.
Ann Oncol. 2004 Feb;15(2):218-23. doi: 10.1093/annonc/mdh050.
The aim of this study was to determine the value of routine follow-up for the detection of recurrence in patients treated for cervical cancer.
From 1986 to 1998, 583 women with stage I and II cervical carcinoma were treated with combined surgery-radiation therapy. After treatment, follow-up was based on clinical examination, a systematic Pap smear and radiography (chest X-ray and abdomino-pelvic ultrasonography).
Forty-five patients had recurrence observed with a delay > or = 6 months following the end of treatment. Thirty-eight patients had symptoms and seven were asymptomatic at the time of their recurrence. Among asymptomatic patients only two recurrences were diagnosed following routine examinations. Survival is similar in asymptomatic and symptomatic recurrent patients.
In conclusion, follow-up of patients treated for cervical cancer based on routine Pap smears and systematic radiography does not permit earlier detection of recurrence and does not increase survival.
本研究的目的是确定宫颈癌治疗患者常规随访对检测复发的价值。
1986年至1998年，583例I期和II期宫颈癌女性接受了手术 - 放疗联合治疗。治疗后，随访基于临床检查、系统性巴氏涂片检查和影像学检查（胸部X线和腹盆腔超声检查）。
45例患者在治疗结束后延迟≥6个月出现复发。38例患者复发时有症状，7例无症状。在无症状患者中，仅通过常规检查诊断出2例复发。无症状和有症状复发患者的生存率相似。
总之，基于常规巴氏涂片检查和系统性影像学检查对宫颈癌治疗患者进行随访，不能早期检测到复发，也不能提高生存率。
