食物直接接触性超敏反应（FICH）与特应性皮炎幼儿的排除饮食。107名儿童的初步结果

Food immediate-contact hypersensitivity (FICH) and elimination diet in young children with atopic dermatitis. Preliminary results in 107 children.

作者信息

Oranje A P, Aarsen R S, Mulder P G, van Toorenenbergen A W, Liefaard G, Dieges P H

机构信息

Department of Dermato-Venereology, Erasmus University, Rotterdam, The Netherlands.

出版信息

Acta Derm Venereol Suppl (Stockh). 1992;176:41-4.

PMID:1476034

Abstract

In atopic dermatitis [AD], not only food consumption, but direct skin-contact too can provoke hypersensitivity reactions. We imitated food immediate-contact hypersensitivity [FICH] to cow's milk, egg, peanut or soy by a skin provocation test. This skin application food test [SAFT] was applied in 91 patients aged up to 5 years and suffering from AD, and in 16 healthy controls (all SAFT-negative). In the SAFT-positive patients (n = 61), FICH to egg was observed in 72%, to cow's milk in 47%, to peanut in 34% and soy in only 1 patient. SAFT and RAST scores correlated weakly. Nevertheless, many discrepancies between SAFT and RAST results were found. In 20 of the 61 (33%) patients with FICH, a flare-up in AD was noted at SAFT testing. Upon introducing dietary restrictions, AD improved impressively in 9 of 23 patients who could be followed up. FICH is an important symptom in children with AD and food allergy.

摘要

在特应性皮炎（AD）中，不仅食物摄入，直接的皮肤接触也会引发过敏反应。我们通过皮肤激发试验模拟了对牛奶、鸡蛋、花生或大豆的食物即刻接触过敏（FICH）。这种皮肤应用食物试验（SAFT）应用于91名5岁及以下患有AD的患者以及16名健康对照者（所有SAFT均为阴性）。在SAFT呈阳性的患者（n = 61）中，72%的患者对鸡蛋呈FICH，47%对牛奶呈FICH，34%对花生呈FICH，只有1名患者对大豆呈FICH。SAFT和RAST评分之间的相关性较弱。然而，发现SAFT和RAST结果之间存在许多差异。在61名（33%）患有FICH的患者中，有20名在SAFT测试时出现了AD病情加重。在引入饮食限制后，23名可随访的患者中有9名的AD病情显著改善。FICH是患有AD和食物过敏的儿童的一个重要症状。