整合素：在癌症发展中的作用及作为治疗靶点
Integrins: roles in cancer development and as treatment targets.
作者信息
Jin H, Varner J
机构信息
John and Rebecca Moores Comprehensive Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0912, USA.
出版信息
Br J Cancer. 2004 Feb 9;90(3):561-5. doi: 10.1038/sj.bjc.6601576.
The integrin family of cell adhesion proteins promotes the attachment and migration of cells on the surrounding extracellular matrix (ECM). Through signals transduced upon integrin ligation by ECM proteins or immunoglobulin superfamily molecules, this family of proteins plays key roles in regulating tumour growth and metastasis as well as tumour angiogenesis. Several integrins play key roles in promoting tumour angiogenesis and tumour metastasis. Antagonists of several integrins (alpha5beta1, alphavbeta3 and alphavbeta5) are now under evaluation in clinical trials to determine their potential as therapeutics for cancer and other diseases.
细胞黏附蛋白的整合素家族促进细胞在周围细胞外基质（ECM）上的附着和迁移。通过细胞外基质蛋白或免疫球蛋白超家族分子与整合素结合时转导的信号，该蛋白家族在调节肿瘤生长、转移以及肿瘤血管生成中发挥关键作用。几种整合素在促进肿瘤血管生成和肿瘤转移中起关键作用。几种整合素（α5β1、αvβ3和αvβ5）的拮抗剂目前正在临床试验中进行评估，以确定它们作为癌症和其他疾病治疗药物的潜力。
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