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整合素在癌症转移中作用的最新见解。

Recent insights into the role of integrins in cancer metastasis.

作者信息

Clezardin P

机构信息

INSERM Research Unit 403, Hôpital Edouard Herriot, Lyon, France.

出版信息

Cell Mol Life Sci. 1998 Jun;54(6):541-8. doi: 10.1007/s000180050182.

DOI:10.1007/s000180050182
PMID:9676573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11147302/
Abstract

Integrins have been repeatedly found involved in cancer metastasis. The past two years have seen considerable evolution in our knowledge on the role of these integrins in tumour cells. This includes the elucidation of different signalling pathways by which integrins dictate the anchorage-independent growth, survival and motility of tumour cells. Moreover, integrins may have a more complex role in cancer metastasis as they cooperate with serine proteases and metalloproteases to promote tumour cell invasion and angiogenesis. Finally, integrins favour tumor cell extravasation.

摘要

整合素已被反复发现与癌症转移有关。在过去两年中，我们对这些整合素在肿瘤细胞中作用的认识有了相当大的进展。这包括阐明整合素通过不同信号通路决定肿瘤细胞的非锚定依赖性生长、存活和迁移的机制。此外，整合素在癌症转移中可能发挥更复杂的作用，因为它们与丝氨酸蛋白酶和金属蛋白酶协同作用以促进肿瘤细胞侵袭和血管生成。最后，整合素有利于肿瘤细胞外渗。