COX-2和mPGES-1在小鼠胃肠道错构瘤中的同时表达。
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
作者信息
Takeda H, Miyoshi H, Tamai Y, Oshima M, Taketo M M
机构信息
Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
出版信息
Br J Cancer. 2004 Feb 9;90(3):701-4. doi: 10.1038/sj.bjc.6601584.
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.
环氧化酶（COX）-2在多种类型的癌组织中被诱导表达。在此，我们证明了在Lkb1(+/-)、Smad4(+/-)和Cdx2(+/-)小鼠发生的胃肠道错构瘤中，COX-2和微粒体前列腺素E(2)合酶（mPGES）-1均有基质表达。这些结果表明，由COX-2和mPGES-1产生的前列腺素E(2)在错构瘤的发生发展中起重要作用，而与导致错构瘤的突变基因无关。
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