Ovaert C, McCrindle B W, Nykanen D, Freedom R M, Benson L N
Department of Pediatrics, The Hospital for Sick Children, The University of Toronto School of Medicine, Toronto, Ontario, Canada.
Can J Cardiol. 2003 Dec;19(13):1493-7.
To assess the efficacy and safety of transcatheter reocclusion of persistent leaks following previously attempted transcatheter occlusion of persistent arterial duct.
Retrospective study.
Tertiary pediatric cardiology centre.
From February 1987 through October 1996, trans-catheter occlusion of a residual ductal shunt was attempted in 42 consecutive patients at a median age of 5.0 years (range 1.6 years to 16.2 years).
Fourty patients had successful placement of a double umbrella occluder (n=27) or coils (n=13) across residual shunts. Complications included device embolization in two patients and hemolysis in one patient.
Mean z-score for left ventricular end-diastolic dimension (LVEDD) at initial echocardiography was +2.55 +/- 1.89 (P<0.0001 versus normal); z-score for left pulmonary artery (LPA) diameter was +2.00 +/- 1.52 (P<0.0001). Mean LPA to right pulmonary artery (RPA) diameter ratio was 1.05 +/- 0.18. At follow-up echocardiogram, a median of two years (range six months to 7.7 years) after the second procedure, a shunt was persistent in 3% of the patients. Mean LVEDD and LPA diameter z-value, and mean LPA to RPA diameter had dropped significantly to +0.42 +/- 1.31, +0.07 +/- 1.15 and 0.86 +/- 0.14 (P<0.001), respectively. LPA flow acceleration was present in 25% of patients. Three of nine patients, in whom lung perfusion scan was performed, had left lung perfusion below 40%. Small weight and age at catheterization were significant risk factors for LPA flow disturbance.
Repeat transcatheter occlusion is safe and successful in eliminating residual shunt across the arterial duct. Attention should, however, be addressed to the potential for LPA stenosis and growth, and flow should be regularly assessed.
评估在先前尝试经导管封堵动脉导管未闭后,经导管再次封堵持续性分流的有效性和安全性。
回顾性研究。
三级儿科心脏病中心。
从1987年2月至1996年10月,连续42例患者尝试经导管封堵残余导管分流,中位年龄5.0岁(范围1.6岁至16.2岁)。
40例患者成功在残余分流处放置双伞封堵器(n = 27)或弹簧圈(n = 13)。并发症包括2例患者发生装置栓塞和1例患者发生溶血。
初始超声心动图检查时左心室舒张末期内径(LVEDD)的平均z值为+2.55±1.89(与正常相比,P<0.0001);左肺动脉(LPA)直径的z值为+2.00±1.52(P<0.0001)。LPA与右肺动脉(RPA)直径的平均比值为1.05±0.18。在第二次手术后中位时间为两年(范围6个月至7.7年)的随访超声心动图检查中,3%的患者存在持续性分流。LVEDD和LPA直径的平均z值以及LPA与RPA直径平均值已显著降至+0.42±1.31、+0.07±1.15和0.86±0.14(P<0.001)。25%的患者存在LPA血流加速。在进行肺灌注扫描的9例患者中,3例左肺灌注低于40%。导管插入时体重小和年龄小是LPA血流紊乱的重要危险因素。
再次经导管封堵在消除动脉导管残余分流方面是安全且成功的。然而,应关注LPA狭窄和生长的可能性,并应定期评估血流情况。