Hornstein O P, Keller J, Boissevain F
Department of Dermatology, University of Erlangen-Nürnberg, FRG.
Acta Derm Venereol Suppl (Stockh). 1992;176:86-9.
There are signs of abnormal microcirculation in atopics, yet reliable methods for its non-invasive measurement are scarce so far. Since the phenomenon of dermographism (D) elicited by blunt stroking of the skin reflects the functional response of cutaneous vessels to pressure, we studied the haemodynamics of D using laser-Doppler microfluxometry (LDF) and infrared thermography (IR-TH) in patients with atopic eczema (n = 23) and in healthy controls (n = 21) under standardized investigative conditions. Only in-patients not treated with corticoids were selected. LDF values showed a marked reduction in the intensity of hyperaemia in the patients as compared with the controls, according to the visual degree of the dermographic blanching effect (white, delayed white, indifferent; pink). A reduction of the radiating skin temperature vis-à-vis the controls was measured by IR-TH. These results yield evidence that dermographic pallor of atopic skin depends on the strength of local vasoconstriction, possibly including altered blood flow in cutaneous shunt vessels.
特应性个体存在微循环异常的迹象，但迄今为止，尚无可靠的非侵入性测量方法。由于皮肤钝性划擦引起的皮肤划痕症（D）现象反映了皮肤血管对压力的功能反应，我们在标准化研究条件下，使用激光多普勒微血流仪（LDF）和红外热成像（IR-TH）对23例特应性皮炎患者和21例健康对照者的皮肤划痕症血流动力学进行了研究。仅选择未接受皮质类固醇治疗的住院患者。根据皮肤划痕症变白效应的视觉程度（白色、延迟变白、无变化；粉红色），LDF值显示患者与对照组相比，充血强度明显降低。通过IR-TH测量发现，与对照组相比，患者皮肤辐射温度降低。这些结果表明，特应性皮肤的划痕症苍白取决于局部血管收缩的强度，可能包括皮肤分流血管中血流的改变。
