浸润性乳腺癌中转化生长因子β、纤连蛋白及纤连蛋白受体的免疫组织化学研究

Immunohistochemical study of transforming growth factor beta, fibronectin, and fibronectin receptor in invasive mammary carcinomas.

作者信息

Oda K, Hori S, Itoh H, Osamura R Y, Tokuda Y, Kubota M, Tajima T

机构信息

Department of Pathology, Tokai University, School of Medicine, Kanagawa, Japan.

出版信息

Acta Pathol Jpn. 1992 Sep;42(9):645-50. doi: 10.1111/j.1440-1827.1992.tb03045.x.

DOI:10.1111/j.1440-1827.1992.tb03045.x

PMID:1476059

Abstract

Thirty-one cases of mammary carcinoma were examined immunohistochemically for the expression of transforming growth factor (TGF) beta, fibronectin (FN) and fibronectin receptor (FNR) in order to clarify the reason for the reported relationship between TGF beta expression and a high incidence of lymph node metastasis. It was revealed that TGF beta expression is closely related to the expression of FN, an intercellular matrix protein, and its cellular receptor FNR, one of the integrins. The interaction between FN and FNR in a tumor is considered to form the basis of the invasive nature of carcinoma cells. Thus, it is suggested that TGF beta expression in carcinoma cells induces the interaction between FN and FNR, which may lead to carcinomatous invasion resulting in lymph nodal metastasis.

摘要

为了阐明转化生长因子（TGF）β表达与淋巴结转移高发生率之间所报道关系的原因，对31例乳腺癌进行了免疫组织化学检查，以检测转化生长因子（TGF）β、纤连蛋白（FN）和纤连蛋白受体（FNR）的表达。结果显示，TGFβ表达与细胞间基质蛋白FN及其细胞受体FNR（整合素之一）的表达密切相关。肿瘤中FN与FNR之间的相互作用被认为是癌细胞侵袭性的基础。因此，提示癌细胞中的TGFβ表达诱导FN与FNR之间的相互作用，这可能导致癌侵袭并进而导致淋巴结转移。