Ustun Sebnem, Aksoy Umit, Dagci Hande, Ersoz Galip
Department of Gastroenterology, School of Medicine, University of Ege, 35100 Bornova, Izmir, Turkey.
World J Gastroenterol. 2004 Feb 1;10(3):452-4. doi: 10.3748/wjg.v10.i3.452.
It is known that toxoplasmosis rarely leads to various liver pathologies, most common of which is granulomatose hepatitis in patients having normal immune systems. Patients who have cirrhosis of the liver are subject to a variety of cellular as well as humoral immunity disorders. Therefore, it may be considered that toxoplasmosis can cause more frequent and more severe diseases in patients with cirrhosis and is capable of changing the course of the disease. The aim of this study was to investigate the frequency of toxoplasmosis in patients with cirrhosis.
Serum samples were taken from 108 patients with cirrhosis under observation in the Hepatology Polyclinic of the Gastroenterology Clinic, and a control group made up of 50 healthy blood donors. IFAT and ELISA methods were used to investigate the IgG and IgM antibodies, which had developed from these sera.
Toxoplasma IgG and IgM antibody positivity was found in 74 (68.5%) of the 108 cirrhotic patients and 24 (48%) of the 50 people in the control group. The difference between them was significant (P<0.05).
In conclusion, it was found that the toxoplasma sero-prevalence in the cirrhotic patients in this study was higher. Cirrhotic patients are likely to form a toxoplasma risk group. More detailed studies are needed on this subject.
已知弓形虫病很少导致各种肝脏病变，其中最常见的是免疫系统正常的患者发生肉芽肿性肝炎。肝硬化患者存在多种细胞免疫和体液免疫紊乱。因此，可以认为弓形虫病在肝硬化患者中可能导致更频繁、更严重的疾病，并且能够改变疾病进程。本研究的目的是调查肝硬化患者中弓形虫病的发生率。
从胃肠病诊所肝病综合门诊观察的108例肝硬化患者中采集血清样本，并选取由50名健康献血者组成的对照组。采用间接荧光抗体试验（IFAT）和酶联免疫吸附测定（ELISA）方法检测这些血清中产生的IgG和IgM抗体。
108例肝硬化患者中有74例（68.5%）弓形虫IgG和IgM抗体呈阳性，对照组50人中24例（48%）呈阳性。两者差异有统计学意义（P<0.05）。
总之，本研究发现肝硬化患者中弓形虫血清阳性率较高。肝硬化患者可能构成弓形虫风险群体。对此主题需要进行更详细的研究。
