Nouri-Aria K T, Alexander G J, Portmann B C, Hegarty J E, Eddleston A L, Williams R
J Hepatol. 1986;2(2):195-207. doi: 10.1016/s0168-8278(86)80078-2.
Increased in vivo synthesis of immunoglobulin in patients with alcoholic liver damage has been attributed to direct activation of B cells, although other defects of lymphocyte function have been identified suggesting a more generalised defect. In the present study we have investigated the role of T cell regulation of immunoglobulin production in alcoholic liver disease analysed according to the presence or absence of alcoholic hepatitis. Spontaneous production of IgG and IgA was elevated and co-culture experiments confirmed hyper-reactivity of B cells, but also suggested impaired T cell function. Suppressor cell activity for IgG and IgA was impaired. Similarly, the response to pokeweed mitogen for IgG and IgA was defective, although this was more marked for secretion than for proliferation suggesting an associated T helper defect. No differences in the immunological abnormalities were identified between those with alcoholic hepatitis and those with other alcoholic liver diseases. This study demonstrates a broad defect of T cells and a hyper-reactivity of B cells in patients with alcoholic liver disease, irrespective of the severity of hepatic inflammation.
酒精性肝损伤患者体内免疫球蛋白合成增加，这归因于B细胞的直接激活，尽管已发现淋巴细胞功能的其他缺陷，提示存在更普遍的缺陷。在本研究中，我们根据是否存在酒精性肝炎，研究了酒精性肝病中T细胞对免疫球蛋白产生的调节作用。IgG和IgA的自发产生增加，共培养实验证实了B细胞的高反应性，但也提示T细胞功能受损。对IgG和IgA的抑制细胞活性受损。同样，对商陆有丝分裂原刺激产生的IgG和IgA反应存在缺陷，尽管分泌方面的缺陷比增殖方面更明显，提示存在相关的辅助性T细胞缺陷。酒精性肝炎患者与其他酒精性肝病患者之间未发现免疫异常有差异。本研究表明，酒精性肝病患者存在广泛的T细胞缺陷和B细胞高反应性，与肝脏炎症的严重程度无关。
