Boldizsár H, Muray T, Számel I, Szenci O, Csenki J
Department of Physiology, University of Veterinary Science, Budapest, Hungary.
Acta Vet Hung. 1992;40(1-2):89-97.
Tissue samples taken from the mammary gland of 42 dogs (age: 6 to 12 years) were examined. Thirty-eight samples showed neoplasia: 36 were epithelial while the remaining 2 proved to be connective tissue tumours. Thirty-four % of the neoplasms were new benign tumours (most frequently adenoma and fibroadenoma) and 66% were malignant ones (mainly adenocarcinoma). The oestrogen receptor (ER) and progesterone receptor (PR) binding capacity was determined on 21 tissue samples using the method of EORTC (1980). The connective tissue tumours and non-tumourous tissues contained no sexual steroid receptor. 71.4% of all tissue samples contained receptors. 61.9% of the samples was ER+, 42.8% was PR+, 33.3% contained both receptors, 28.6% was only ER+ and 9.5% only PR+. The average ER and PR binding capacity was 120.3 (5.0-622.8) and 266.7 (92.3-475.0) fmol/mg cytosol protein, respectively. No difference in receptor positivity was demonstrable between the benign and the malignant tumours. PR negativity accompanied by ER positivity was more common in the case of benign tumours. ER binding capacity tended to be correlated with age: this correlation could be described with a hyperboloid regression curve (r = -0.5931; 0.06 > p > 0.05).
对42只犬（年龄6至12岁）的乳腺组织样本进行了检查。38个样本显示有肿瘤形成：36个为上皮性肿瘤，其余2个为结缔组织肿瘤。34%的肿瘤为新的良性肿瘤（最常见的是腺瘤和纤维腺瘤），66%为恶性肿瘤（主要是腺癌）。采用欧洲癌症研究与治疗组织（EORTC，1980年）的方法对21个组织样本测定了雌激素受体（ER）和孕激素受体（PR）的结合能力。结缔组织肿瘤和非肿瘤组织中未检测到性类固醇受体。所有组织样本中有71.4%含有受体。61.9%的样本ER阳性，42.8%的样本PR阳性，33.3%的样本同时含有两种受体，28.6%的样本仅ER阳性，9.5%的样本仅PR阳性。ER和PR的平均结合能力分别为120.3（5.0 - 622.8）和266.7（92.3 - 475.0）fmol/mg胞浆蛋白。良性肿瘤和恶性肿瘤之间在受体阳性方面无明显差异。良性肿瘤中PR阴性伴ER阳性更为常见。ER结合能力与年龄呈一定相关性：这种相关性可用双曲面回归曲线描述（r = -0.5931；0.06 > p > 0.05）。
