Bombardier C H, Blake K D, Ehde D M, Gibbons L E, Moore D, Kraft G H
Department of Rehabilitation Medicine, Box 359740, Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA.
Mult Scler. 2004 Feb;10(1):35-40. doi: 10.1191/1352458504ms989oa.
To examine the one-month prevalence and impact of substance abuse in a large community sample of persons with multiple sclerosis (MS).
Members of the Multiple Sclerosis Society of King County were surveyed by mail. This multifaceted health survey included questions pertaining to substance abuse. Seven hundred and thirty-nine out of 1374 potential participants (54%) returned the survey, while 708 reported a medically confirmed diagnosis of MS and provided sufficient data.
Fourteen per cent of the sample screened positive for possible alcohol abuse or dependence, and 7.4% reported misusing illicit drugs or prescription medications within the previous month. Possible alcohol abuse and drug misuse were associated with younger age, less severe MS related disability and being employed, as well as greater self-reported depressive symptomatology. Most persons with alcohol problems indicated interest in learning more about ways to stop or cut down.
Substance abuse may be present in up to 19% of this sample and contribute to high rates of depression. There may be greater risk of harm due to substance abuse in people with MS because of the potential magnification of motor and cognitive impairments. Comprehensive MS care should include substance abuse screening and advice to cut down or abstain.
在一个大型多发性硬化症（MS）社区样本中，研究药物滥用的1个月患病率及其影响。
通过邮件对金县多发性硬化症协会的成员进行调查。这项多方面的健康调查包括与药物滥用有关的问题。1374名潜在参与者中有739人（54%）回复了调查，其中708人报告经医学确诊患有MS并提供了足够的数据。
14%的样本筛查出可能存在酒精滥用或依赖，7.4%的人报告在前一个月内滥用非法药物或处方药。可能的酒精滥用和药物滥用与年龄较小、MS相关残疾不太严重、就业以及自我报告的抑郁症状较多有关。大多数有酒精问题的人表示有兴趣了解更多关于戒酒或减少饮酒的方法。
该样本中高达19%的人可能存在药物滥用问题，并导致高抑郁率。由于运动和认知障碍可能会加重，MS患者因药物滥用而受到伤害的风险可能更大。全面的MS护理应包括药物滥用筛查以及减少或戒除药物的建议。
