Wang Shui-ming, Wang De-wen, Peng Rui-yun, Chen Hao-yu, Gao Ya-bing, Cao Xiao-zhe, Cui Xue-mei, Zhao Mei-lan
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003 Oct;21(5):329-31.
To evaluate the effect of electromagnetic pulse (EMP) irradiation on mice reproduction.
Female/male Kunming mice, 6 - 8 weeks old, prior to mating, or female after pregnancy were treated with whole body irradiation by 6 x 10(4) V/m electromagnetic pulse (EMP) for five times. The pregnant mice were killed on the 18th days, and teratological markers were analysed.
EMP irradiation caused no significant changes in most of female organ weight and organ/body weight ratio. But it caused significant shortening in tail length of live foetus in the female mice before conception (prior to mating) or after pregnancy (P < 0.05), and obvious decrease in male offspring ratio (0.85 +/- 0.09 vs 1.09 +/- 0.17, P < 0.05). The male offspring ratio also significantly decreased (0.76 +/- 0.18 vs 1.09 +/- 0.17, P < 0.01) after male mice irradiated by EMP. The tail length of live foetus was shortened and male offspring sex ratio was increased after both male and female mice were irradiated by EMP. EMP irradiation also caused a significantly higher fetal death rate than normal control (P < 0.05). The embryo absorption rate was increased after irradiation except that was decreased in male mice.
EMP irradiation has effect on pregnancy and offspring development in both male and female mice before mating and in female mice after pregnancy.
评估电磁脉冲（EMP）辐照对小鼠生殖的影响。
6 - 8周龄的雌性/雄性昆明小鼠，在交配前或雌性怀孕后，用6×10⁴V/m的电磁脉冲（EMP）进行全身辐照，共5次。怀孕小鼠在第18天处死，分析致畸指标。
EMP辐照对大多数雌性器官重量和器官/体重比无显著影响。但在受孕前（交配前）或怀孕后的雌性小鼠中，它导致活胎尾长显著缩短（P < 0.05），雄性后代比例明显降低（0.85±0.09对1.09±0.17，P < 0.05）。雄性小鼠经EMP辐照后，雄性后代比例也显著降低（0.76±0.18对1.09±0.17，P < 0.01）。雌雄小鼠经EMP辐照后，活胎尾长缩短，雄性后代性别比例增加。EMP辐照还导致胎儿死亡率显著高于正常对照组（P < 0.05）。辐照后胚胎吸收率增加，但雄性小鼠除外。
EMP辐照对交配前的雌雄小鼠以及怀孕后的雌性小鼠的妊娠和后代发育均有影响。
