已获许可的抗真菌药物与新型抗真菌药物对镰刀菌属的体外相互作用
In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
作者信息
Ortoneda Montserrat, Capilla Javier, Javier Pastor F, Pujol Isabel, Guarro Josep
机构信息
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain.
出版信息
Diagn Microbiol Infect Dis. 2004 Jan;48(1):69-71. doi: 10.1016/j.diagmicrobio.2003.09.003.
We have studied the in vitro interactions of amphotericin B (AMB) with terbinafine (TBF), itraconazole, voriconazole (VCZ), albaconazole, and ravuconazole (RVZ), as well as TBF combined with the same azoles, against 11 isolates of Fusarium spp. using the fractional inhibitory concentration index. The highest percentage of synergistic interactions was observed for the combinations AMB-RVZ, TBF-VCZ, and TBF-RCZ.
我们使用部分抑菌浓度指数，研究了两性霉素B（AMB）与特比萘芬（TBF）、伊曲康唑、伏立康唑（VCZ）、阿巴康唑和雷夫康唑（RVZ）以及TBF与相同唑类药物联合，对11株镰刀菌属菌株的体外相互作用。对于AMB-RVZ、TBF-VCZ和TBF-RCZ组合，观察到的协同相互作用百分比最高。
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