• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿尼芬净与伊曲康唑、伏立康唑及两性霉素B针对曲霉属和镰刀菌属进行的体外协同试验

In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.

作者信息

Philip Annie, Odabasi Zekaver, Rodriguez Jose, Paetznick Victor L, Chen Enuo, Rex John H, Ostrosky-Zeichner Luis

机构信息

Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas-Houston Medical School, 6431 Fannin, MSB 2.112, Houston, TX 77030, USA.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3572-4. doi: 10.1128/AAC.49.8.3572-3574.2005.

DOI:10.1128/AAC.49.8.3572-3574.2005
PMID:16048988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196215/
Abstract

The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.

摘要

采用棋盘法评估了阿尼芬净与伊曲康唑、伏立康唑和两性霉素B的体外相互作用。对于曲霉属菌株，阿尼芬净与两性霉素B对16/26株分离菌表现为无关作用，而阿尼芬净与任一唑类药物对18/26株分离菌表现出协同趋势。所有药物组合对7/7株76株镰刀菌属分离菌均表现为无关作用。

相似文献

1
In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp.阿尼芬净与伊曲康唑、伏立康唑及两性霉素B针对曲霉属和镰刀菌属进行的体外协同试验
Antimicrob Agents Chemother. 2005 Aug;49(8):3572-4. doi: 10.1128/AAC.49.8.3572-3574.2005.
2
In vitro activity of voriconazole, itraconazole, caspofungin, anidulafungin (VER002, LY303366) and amphotericin B against aspergillus spp.伏立康唑、伊曲康唑、卡泊芬净、阿尼芬净（VER002，LY303366）及两性霉素B对曲霉属真菌的体外活性
Diagn Microbiol Infect Dis. 2003 Feb;45(2):131-5. doi: 10.1016/s0732-8893(02)00507-2.
3
Combined activity in vitro of caspofungin, amphotericin B, and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus.卡泊芬净、两性霉素B和唑类药物对耐伊曲康唑烟曲霉临床分离株的体外联合活性。
Antimicrob Agents Chemother. 2005 Mar;49(3):1232-5. doi: 10.1128/AAC.49.3.1232-1235.2005.
4
Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis.从角膜炎中分离出的镰刀菌、曲霉菌及其他丝状真菌的药敏性
Arch Ophthalmol. 2007 Jun;125(6):789-93. doi: 10.1001/archopht.125.6.789.
5
In vitro susceptibility testing of Candida and Aspergillus spp. to voriconazole and other antifungal agents using Etest: results of a French multicentre study.使用Etest对念珠菌和曲霉属进行伏立康唑及其他抗真菌药物的体外药敏试验：一项法国多中心研究的结果
Int J Antimicrob Agents. 2005 Apr;25(4):321-8. doi: 10.1016/j.ijantimicag.2004.11.010.
6
Microdilution susceptibility testing of amphotericin B, itraconazole, and voriconazole against clinical isolates of Aspergillus and Fusarium species.两性霉素B、伊曲康唑和伏立康唑对曲霉属和镰刀菌属临床分离株的微量稀释药敏试验。
J Clin Microbiol. 1999 Dec;37(12):3946-51. doi: 10.1128/JCM.37.12.3946-3951.1999.
7
Effect of voriconazole combined with micafungin against Candida, Aspergillus, and Scedosporium spp. and Fusarium solani.伏立康唑联合米卡芬净对念珠菌、曲霉菌、赛多孢属菌及茄病镰刀菌的作用。
Antimicrob Agents Chemother. 2005 Dec;49(12):5157-9. doi: 10.1128/AAC.49.12.5157-5159.2005.
8
In vitro susceptibility testing of Aspergillus spp. against voriconazole, itraconazole, posaconazole, amphotericin B and caspofungin.曲霉属真菌对伏立康唑、伊曲康唑、泊沙康唑、两性霉素 B 和卡泊芬净的体外药敏试验。
Chin Med J (Engl). 2010 Oct;123(19):2706-9.
9
Antifungal interactions within the triple combination of amphotericin B, caspofungin and voriconazole against Aspergillus species.两性霉素B、卡泊芬净和伏立康唑三联组合对曲霉菌的抗真菌相互作用。
J Antimicrob Chemother. 2006 Dec;58(6):1168-76. doi: 10.1093/jac/dkl392. Epub 2006 Oct 27.
10
Comparative in vitro activities of posaconazole, voriconazole, itraconazole, and amphotericin B against Aspergillus and Rhizopus, and synergy testing for Rhizopus.泊沙康唑、伏立康唑、伊曲康唑和两性霉素B对曲霉和根霉的体外活性比较以及根霉的协同试验。
Med Mycol. 2008 Sep;46(6):567-73. doi: 10.1080/13693780801975576.

引用本文的文献

1
Antifungal Resistance in Non-fumigatus Aspergillus Species.非烟曲霉属真菌中的抗真菌耐药性
Mycoses. 2025 Apr;68(4):e70051. doi: 10.1111/myc.70051.
2
CAF to the Rescue! Potential and Challenges of Combination Antifungal Therapy for Reducing Morbidity and Mortality in Hospitalized Patients With Serious Fungal Infections.CAF来救援！联合抗真菌治疗在降低严重真菌感染住院患者发病率和死亡率方面的潜力与挑战。
Open Forum Infect Dis. 2024 Oct 30;11(11):ofae646. doi: 10.1093/ofid/ofae646. eCollection 2024 Nov.
3
and evaluation of antifungal combinations against azole-resistant isolates.并评估抗真菌药物联合治疗对唑类耐药分离株的效果。
Front Cell Infect Microbiol. 2023 Jan 17;12:1038342. doi: 10.3389/fcimb.2022.1038342. eCollection 2022.
4
Efficacy and safety of combination antifungal therapy in Korean haematological patients with invasive aspergillosis.联合抗真菌治疗在韩国血液系统侵袭性曲霉病患者中的疗效和安全性。
Mycoses. 2019 Oct;62(10):969-978. doi: 10.1111/myc.12972. Epub 2019 Aug 18.
5
Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus.唑类药物诱导的细胞壁碳水化合物补丁杀死烟曲霉。
Nat Commun. 2018 Aug 6;9(1):3098. doi: 10.1038/s41467-018-05497-7.
6
Endogenous Fusarium Endophthalmitis During Treatment for Acute Myeloid Leukemia, Successfully Treated with 25-Gauge Vitrectomy and Antifungal Medications.急性髓系白血病治疗期间并发内源性镰刀菌眼内炎，25G 玻璃体切除术联合抗真菌药物治疗成功。
Mycopathologia. 2018 Apr;183(2):451-457. doi: 10.1007/s11046-017-0221-x. Epub 2017 Dec 16.
7
Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp.伊曲康唑联合棘白菌素类药物治疗唑类敏感和耐药的曲霉菌属
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01382-17. Print 2018 Jan.
8
Population pharmacokinetic analysis of voriconazole and anidulafungin in adult patients with invasive aspergillosis.伏立康唑和阿尼芬净在成年侵袭性曲霉病患者中的群体药代动力学分析。
Antimicrob Agents Chemother. 2014 Aug;58(8):4718-26. doi: 10.1128/AAC.02808-13. Epub 2014 Jun 9.
9
In vitro interaction of voriconazole and anidulafungin against triazole-resistant Aspergillus fumigatus.体外伏立康唑和阿尼芬净对唑类耐药烟曲霉的相互作用。
Antimicrob Agents Chemother. 2013 Feb;57(2):796-803. doi: 10.1128/AAC.00980-12. Epub 2012 Nov 26.
10
Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis.伏立康唑联合安尼卡霉素治疗侵袭性肺曲霉病体外模型中三唑类耐药烟曲霉。
Antimicrob Agents Chemother. 2012 Oct;56(10):5180-5. doi: 10.1128/AAC.01111-12. Epub 2012 Jul 23.

本文引用的文献

1
Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy.卡泊芬净治疗对传统抗真菌治疗难治或不耐受的侵袭性曲霉病患者的疗效和安全性。
Clin Infect Dis. 2004 Dec 1;39(11):1563-71. doi: 10.1086/423381. Epub 2004 Nov 9.
2
Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations.卡泊芬净的矛盾效应：在高药物浓度下对白色念珠菌的活性降低。
Antimicrob Agents Chemother. 2004 Sep;48(9):3407-11. doi: 10.1128/AAC.48.9.3407-3411.2004.
3
Combination antifungal therapy.联合抗真菌治疗。
Antimicrob Agents Chemother. 2004 Mar;48(3):693-715. doi: 10.1128/AAC.48.3.693-715.2004.
4
Experimental approach to the problem of treatment failure with penicillin. I. Group A streptococcal infection in mice.青霉素治疗失败问题的实验方法。I. 小鼠A组链球菌感染
Am J Med. 1952 Oct;13(4):389-99. doi: 10.1016/0002-9343(52)90293-3.
5
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.联合治疗实验性肺曲霉病：抗真菌三唑类药物与棘白菌素之间的协同相互作用
J Infect Dis. 2003 Jun 15;187(12):1834-43. doi: 10.1086/375420. Epub 2003 Jun 4.
6
The first echinocandin: caspofungin.首个棘白菌素类药物：卡泊芬净。
Mycoses. 2002;45 Suppl 3:56-60. doi: 10.1111/j.1439-0507.2002.tb04771.x.
7
Systemic mycoses in the immunocompromised host: an update in antifungal therapy.免疫功能低下宿主的系统性真菌病：抗真菌治疗的最新进展。
J Hosp Infect. 2003 Apr;53(4):243-58. doi: 10.1053/jhin.2002.1278.
8
Comparison of in vitro antifungal activities of amphotericin B lipid complex with itraconazole against 708 clinical yeast isolates and opportunistic moulds determined by National Committee for Clinical Laboratory Standards methods M27-A and M38-P.采用美国国家临床实验室标准委员会M27-A和M38-P方法，比较两性霉素B脂质复合物与伊曲康唑对708株临床酵母分离株和机会性霉菌的体外抗真菌活性。
Chemotherapy. 2002 Dec;48(5):224-31. doi: 10.1159/000066764.
9
Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.伏立康唑与两性霉素B用于侵袭性曲霉病的初始治疗比较
N Engl J Med. 2002 Aug 8;347(6):408-15. doi: 10.1056/NEJMoa020191.
10
Efficacy of caspofungin alone and in combination with voriconazole in a Guinea pig model of invasive aspergillosis.卡泊芬净单独及与伏立康唑联合在豚鼠侵袭性曲霉病模型中的疗效。
Antimicrob Agents Chemother. 2002 Aug;46(8):2564-8. doi: 10.1128/AAC.46.8.2564-2568.2002.