Bajdekoff B, Bojkov B, Durmischev A
Allerg Immunol (Leipz). 1977;23(4):310-2.
The number and morphological changes of the mast cells were studied in the skin of three groups white rats. The first group was treated subcutaneously with 5 mg/kg body weight chloroquine diphosphate for twenty days, the second group was treated with saline; the third group was not treated at all. An absolute increase of the number of mast cells in the animals treated with chloroquine diphosphate was established. It was assumed the increase of the mast cells is connected with the activation of the histidine-decarboxylase and the rise of the histamine level in the site of chloroquine diphosphate application.
研究了三组白鼠皮肤中肥大细胞的数量和形态变化。第一组以5毫克/千克体重的二磷酸氯喹皮下注射处理二十天，第二组用生理盐水处理；第三组未作任何处理。已确定用二磷酸氯喹处理的动物体内肥大细胞数量绝对增加。据推测，肥大细胞的增加与组氨酸脱羧酶的激活以及二磷酸氯喹应用部位组胺水平的升高有关。
