Teymoortash Afshin, Ramaswamy Annette, Werner Jochen Alfred
Department of Otolaryngology, Head and Neck Surgery, Philipps University, Marburg 35037, Germany.
J Oral Sci. 2003 Dec;45(4):233-5. doi: 10.2334/josnusd.45.233.
The exact cause of the formation of sialoliths is unknown. Detailed knowledge of the pathogenesis of sialolithiasis is necessary to define new therapeutic procedures. The possible presence of a sphincter system in Wharton's duct has been described frequently in the context of diagnostic sialendoscopy. Serial histological examination of the entire Wharton's duct in four samples revealed no anatomical correlation for the presence of a sphincter. Secretory disturbances and viscous secretions as well as microlith formation and ductal obstruction cannot fully explain the genesis of sialoliths. The coaction of those factors with participation of bacteria leads to the development of sialoliths.
涎石形成的确切原因尚不清楚。了解涎石病的发病机制细节对于确定新的治疗方法很有必要。在诊断性涎腺内镜检查中，经常会提到沃顿管中可能存在括约肌系统。对四个样本中的整个沃顿管进行连续组织学检查，未发现存在括约肌的解剖学关联。分泌紊乱、黏稠分泌物以及微石形成和导管阻塞并不能完全解释涎石的成因。这些因素与细菌共同作用导致了涎石的形成。
