Jain S K, Uppal R P, Garg B D
Tierärztliche Hochschule Hannover, Institut für Pharmakologie, Toxikologie und Pharmazie, Germany.
Ann Rech Vet. 1992;23(4):389-93.
Pharmacokinetics and urinary excretion of sulfadiazine were determined in buffalo calves following single oral administration (150 mg/kg). Kinetic evaluation of plasma levels was performed using a 2-compartment model. The absorption half-life and elimination half-life were 3.41 +/- 0.63 and 13.75 +/- 1.94 h, respectively. Based on this study, an optimal dosage regimen of sulfadiazine in buffalo calves would be 165 mg/kg, followed by 75 mg/kg at 12-h intervals. Sulfadiazine was mainly excreted in the urine as free amine, while the percentage of acetylated sulfadiazine was comparatively low.
在单次口服给予（150毫克/千克）磺胺嘧啶后，测定了水牛犊牛体内磺胺嘧啶的药代动力学和尿排泄情况。使用二室模型对血浆水平进行动力学评估。吸收半衰期和消除半衰期分别为3.41±0.63小时和13.75±1.94小时。基于本研究，水牛犊牛磺胺嘧啶的最佳给药方案为165毫克/千克，随后每隔12小时给予75毫克/千克。磺胺嘧啶主要以游离胺形式经尿液排泄，而乙酰化磺胺嘧啶的比例相对较低。
