Porta Eduardo A, Berra Alejandro, Monserrat Alberto J, Benavides Sebastian H
Department of Pathology, School of Medicine, University of Hawaii, 1960 East-West Road, Honolulu, HI 96822, USA.
Arch Gerontol Geriatr. 2002 May-Jun;34(3):193-203. doi: 10.1016/s0167-4943(01)00224-2.
The persistent indiscriminate use of the term lipofuscin for the pigments encountered in pathological conditions, and which should be most properly termed ceroid pigments, is still creating unnecessary conceptual and nomenclature problems, and a great deal of confusion. While both the age-dependent lipofuscin and the pathologically formed ceroid pigments have somewhat similar physical and histochemical properties, sufficient differences to properly identify these two types of pigments are presented in this communication. In addition, because little is known on the saccharide components of lipofuscin and ceroid pigments in situ, we have in recent years explored the lectin binding characteristics of lipofuscin in human and rats, as well as in diverse ceroid pigments experimentally induced in rats. Our lectin histochemical results showed qualitative and quantitative differences in the saccharide composition between human cerebral neurolipofuscin and the intra and extracellular ceroid pigment of human atheromas, as well as, between rat lipofuscin and the ceroid pigments induced in these animals.
在病理状况下遇到的色素，持续不加区分地将其称为脂褐素（而实际上最恰当的称呼应该是类蜡样色素），这仍然在制造不必要的概念和命名问题，以及大量的混淆。虽然与年龄相关的脂褐素和病理形成的类蜡样色素在物理和组织化学性质上有一些相似之处，但本交流中展示了足以正确识别这两种色素的差异。此外，由于对原位脂褐素和类蜡样色素的糖类成分了解甚少，我们近年来研究了人及大鼠脂褐素以及大鼠实验诱导产生的各种类蜡样色素的凝集素结合特性。我们的凝集素组织化学结果显示，人类脑神经元脂褐素与人动脉粥样硬化斑块细胞内和细胞外类蜡样色素之间，以及大鼠脂褐素与这些动物体内诱导产生的类蜡样色素之间，在糖类组成上存在定性和定量差异。
