Metzger Joseph M, Westfall Margaret V
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Mich 48109, USA.
Circ Res. 2004 Feb 6;94(2):146-58. doi: 10.1161/01.RES.0000110083.17024.60.
Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.
肌钙蛋白对于心脏收缩的调节至关重要。肌钙蛋白是一种肌节分子开关，与细胞内钙信号协同直接调节收缩事件。已知肌钙蛋白亚型转换、错义突变、蛋白水解切割和翻译后修饰会直接影响肌节调节。作为关于健康和疾病状态下心脏细肌丝功能的主题系列的一部分，本综述重点关注肌钙蛋白中与生理相关的共价和非共价修饰。
