Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein.

作者信息

Boado Ruben J, Li Jian Yi, Pardridge William M

机构信息

Department of Medicine, University of California at Los Angeles, CA 90024, USA.

出版信息

Pediatr Res. 2004 Apr;55(4):557-60. doi: 10.1203/01.PDR.0000113461.07950.72. Epub 2004 Feb 5.

The expression of the blood-brain barrier (BBB) LAT1 large neutral amino acid transporter mRNA and protein was investigated in development in rabbits. The BBB LAT1 mRNA was down-regulated with postnatal development. However, the BBB immunoreactive LAT1 protein was unchanged in postnatal development, despite an up-regulation of the BBB GLUT1 glucose transporter protein during this period. The dissociation between LAT1 protein and mRNA levels in development is consistent with posttranscriptional regulation of BBB LAT1 gene expression.