Marteau P, Daniel F, Seksik P, Jian R
Department of Gastroenterology, Georges Pompidou European Hospital, Paris, and University of Paris V, France.
Endoscopy. 2004 Feb;36(2):130-6. doi: 10.1055/s-2004-814180.
This article reviews a selection of 50 papers on inflammatory bowel disease published between April 2002 and August 2003. The new information and progress summarized here includes: the role of bacteria, their interaction with CARD15/NOD2 gene products and the modulating effects of probiotics; new imaging techniques, such as wireless capsule endoscopy and chromoendoscopy for detecting dysplasia, and fecal markers. It has not been possible to review every aspect of treatment, and the focus here is on factors capable of predicting the efficacy and tolerance of infliximab and new treatments, including natalizumab, thalidomide, cyclophosphamide and 6-thioguanine.
本文回顾了2002年4月至2003年8月间发表的50篇关于炎症性肠病的论文。这里总结的新信息和进展包括：细菌的作用、它们与CARD15/NOD2基因产物的相互作用以及益生菌的调节作用；新的成像技术，如用于检测发育异常的无线胶囊内镜和色素内镜，以及粪便标志物。不可能对治疗的每个方面都进行综述，这里的重点是能够预测英夫利昔单抗和包括那他珠单抗、沙利度胺、环磷酰胺和6-硫鸟嘌呤在内的新治疗方法的疗效和耐受性的因素。
