Watt James P, O'Brien Katherine L, Benin Andrea L, Whitney Cynthia G, Robinson Katherine, Parkinson Alan J, Reid Raymond, Santosham Mathuram
Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis. 2004 Feb 15;38(4):496-501. doi: 10.1086/381198. Epub 2004 Jan 28.
Compared with white and black persons in the United States, some Native American groups are at increased risk for invasive pneumococcal disease (IPD). To characterize the epidemiology of IPD among Navajo adults, we conducted active surveillance for IPD on the Navajo Nation and reviewed medical records of patients with IPD. For 1997-1998, the annual incidence (cases per 100,000 persons) was 56 for Navajos aged 18-64 years and 190 for Navajos aged > or =65 years. The corresponding rates were 10 and 57 for white and 44 and 82 for black persons in the United States. The case-fatality rate was 14%. Eighty percent of cases were caused by serotypes included in the 23-valent pneumococcal polysaccharide vaccine. Navajo adults have rates of IPD that are 3-5-fold higher than those of the general US population. Additional research is needed to understand the reasons for this elevated risk and to develop prevention strategies.
与美国的白人和黑人相比，一些美国原住民群体患侵袭性肺炎球菌疾病（IPD）的风险更高。为了描述纳瓦霍族成年人中IPD的流行病学特征，我们在纳瓦霍族保留地对IPD进行了主动监测，并查阅了IPD患者的病历。1997 - 1998年，18 - 64岁纳瓦霍人的年发病率（每10万人中的病例数）为56，65岁及以上纳瓦霍人的年发病率为190。美国白人的相应发病率为10和57，黑人的相应发病率为44和82。病死率为14%。80%的病例由23价肺炎球菌多糖疫苗包含的血清型引起。纳瓦霍族成年人的IPD发病率比美国普通人群高3至5倍。需要进一步研究以了解这种风险升高的原因并制定预防策略。
