Fleming Catherine A, Christiansen Demian, Nunes David, Heeren Timothy, Thornton David, Horsburgh C Robert, Koziel Margaret James, Graham Camilla, Craven Donald E
Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Clin Infect Dis. 2004 Feb 15;38(4):572-8. doi: 10.1086/381263. Epub 2004 Jan 26.
Health-related quality of life (HRQOL) is diminished in patients infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV), but the effect of HIV/HCV coinfection on HRQOL is unknown. We compared the HRQOL of urban HIV/HCV coinfected patients with that of patients infected with either HCV or HIV alone. We then compared the 3 groups with a US population sample, adjusting for demographic characteristics. HRQOL for the group of HIV/HCV coinfected patients was statistically similar to that of HRQOL in patients with either HCV or HIV alone, but the 3 groups had a significantly decreased HRQOL than did the adjusted US population. Using multivariate techniques, we determined that age, unemployment, injection drug use, and depression were associated with impaired HRQOL. These findings underscore the importance of a multidisciplinary approach to the treatment of these patient populations.
丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）双重感染患者的健康相关生活质量（HRQOL）会下降，但HIV/HCV合并感染对HRQOL的影响尚不清楚。我们比较了城市地区HIV/HCV合并感染患者与单独感染HCV或HIV患者的HRQOL。然后，我们将这三组与美国人群样本进行比较，并对人口统计学特征进行了调整。HIV/HCV合并感染患者组的HRQOL在统计学上与单独感染HCV或HIV患者的HRQOL相似，但这三组的HRQOL明显低于经调整的美国人群。使用多变量技术，我们确定年龄、失业、注射吸毒和抑郁与HRQOL受损有关。这些发现强调了采用多学科方法治疗这些患者群体的重要性。
