Maurer Toby, Rodrigues Lori K E, Ameli Niloufar, Phanuphak Nittaya, Gange Stephen J, DeHovitz Jack, French Audrey L, Glesby Marshall, Jordan Carol, Khalsa Ann, Hessol Nancy A
Department of Dermatology, University of California, San Francisco, California, USA.
Clin Infect Dis. 2004 Feb 15;38(4):579-84. doi: 10.1086/381264. Epub 2004 Jan 30.
The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema, folliculitis, tinea pedis, and xerosis than were women who had not initiated HAART, independent of CD4+ cell count. Participants who had a prior history of a nadir CD4+ cell count of <200 cells/microL and recent CD4+ cell counts of 200-349 cells/microL were more likely to have eczema and xerosis than were women with a nadir CD4+ cell count of >200 cells/microL and recent CD4+ cell counts of >349 cells/microL. An HIV-1 RNA load of >100,000 copies/mL was associated with increased prevalence of herpes zoster infection (odds ratio, 6.10; 95% confidence interval, 2.00-18.65). History of injection drug use was associated with a higher prevalence of onychomycosis, tinea pedis, and xerosis. Molluscum contagiosum was more prevalent among younger women.
在多中心前瞻性研究“女性机构间HIV研究”中，对878名感染1型人类免疫缺陷病毒（HIV-1）的女性评估了高效抗逆转录病毒疗法（HAART）对皮肤病的影响。与未开始HAART治疗的女性相比，接受HAART治疗的HIV-1感染女性患湿疹、毛囊炎、足癣和皮肤干燥的可能性更小，这与CD4+细胞计数无关。既往最低点CD4+细胞计数<200个/微升且近期CD4+细胞计数为200 - 349个/微升的参与者比最低点CD4+细胞计数>200个/微升且近期CD4+细胞计数>349个/微升的女性更易患湿疹和皮肤干燥。HIV-1 RNA载量>100,000拷贝/毫升与带状疱疹感染患病率增加相关（比值比，6.10；95%置信区间，2.00 - 18.65）。注射吸毒史与甲癣、足癣和皮肤干燥的较高患病率相关。传染性软疣在年轻女性中更为普遍。
