Masui F, Yokoyama R, Soshi S, Beppu Y, Asanuma K, Fujii K
Department of Orthopaedic Surgery, Jikei University School of Medicine, National Cancer Centre Hospital, Tokyo, Japan.
J Bone Joint Surg Br. 2004 Jan;86(1):113-5.
A malignant peripheral nerve-sheath tumour developed in the right S1 nerve root in a man aged 30 causing back pain and sciatica. CT and MRI revealed a destructive tumour of the sacrum invading the retroperitoneal space. The tumour was not resectable with an adequate margin. Chemotherapy, consisting of high-dose ifosfamide followed by a combination of vincristine, doxorubicin and cyclophosphamide, was given with success. Malignant peripheral nerve-sheath tumours are thought to respond weakly to chemotherapy, but the response in our patient was complete.
一名30岁男性的右侧S1神经根发生了恶性周围神经鞘瘤，导致背痛和坐骨神经痛。CT和MRI显示骶骨有一个破坏性肿瘤，侵犯了腹膜后间隙。该肿瘤无法进行有足够切缘的切除。给予了由大剂量异环磷酰胺，随后联合长春新碱、阿霉素和环磷酰胺组成的化疗，取得了成功。恶性周围神经鞘瘤被认为对化疗反应较弱，但我们患者的反应是完全缓解。
