Rocha B, Vassalli P, Guy-Grand D
Institut National de la Santé et de la Recherche Médicale, Hôpital Necker, Paris, France.
Immunol Today. 1992 Nov;13(11):449-54. doi: 10.1016/0167-5699(92)90074-H.
In normal mice, not all T-lineage cells are generated and selected in the thymus; an alternative, extrathymic, development pathway exists. Extrathymic T cells are rare in the spleen and lymph nodes, but are abundant in some tissues, such as the gut. Here, Benedita Rocha, Pierre Vassalli and Delphine Guy-Grand discuss the rules of selection of extrathymic T cells, assess the possible role of these cells in the defence of epithelial integrity and their potential role in autoimmune disease.
在正常小鼠中，并非所有T谱系细胞都是在胸腺中产生和选择的；存在另一种胸腺外发育途径。胸腺外T细胞在脾脏和淋巴结中很少见，但在某些组织中很丰富，比如肠道。在此，贝内迪塔·罗查、皮埃尔·瓦萨利和德尔菲娜·居伊 - 格兰讨论了胸腺外T细胞的选择规则，评估了这些细胞在维护上皮完整性防御中的可能作用以及它们在自身免疫性疾病中的潜在作用。
